cdc42: cell division control homolog 42
Shown below are cdc42 amino acid (aa) sequences in FASTA format of four species with a various degree of evolutionary relationship, which is illustrated by the use of phylogenetic tree obtained from NCBI Taxonomy Browser (http://www.ncbi.nlm.nih.gov/Taxonomy/CommonTree/wwwcmt.cgi).
Fasta sequences show that there is 94.8% and 99.5 % aa sequence conservation for human isoform 1 and 2 respectively with a cdc42 homologue in another primate (macaca fascicularis).
There is 94.2 % and 98.9% conservation for human isoform 1 and 2 respectively compared with cdc42 homologue of an another placental mammal (mus muscularis).
78.5 % and 80.6 % aa conservation for human isoform 1 and 2 respectively with cdc42 homologue of an unicellular eukaryote (Saccharomyces cerevisiae).
More detailed analysis of aa seqence conservation of human cdc42 in homologue proteins of other species can be found in the -multiple sequence alignments- tab. For more information about the difference between a protein isoform and a homologue go to -representative proteins- tab.
Homo Sapiens (Modern Human)
>Crab-eating macaque cdc42 homologue protein
MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFNNYAVTVMIGGEPYTLGLFDTAG
QEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLR
DDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQKGLKNVFDEAILAALEPP
EPKKSRRCVLL
>Human cdc42 isoform 1 (cell division control homolog 42)
MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAG
QEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLR
DDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQRGLKNVFDEAILAALEPP
ETQPKRKCCIF
>Human cdc42 isoform 2
MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAG
QEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLR
DDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQKGLKNVFDEAILAALEPP
EPKKSRRCVLL
>House mouse cdc42 homologue protein
MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAG
QEDYDGLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLR
DDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQKGLKNVFDGAILAALEPP
EPKKSRRCVLL
>Baker's yeast cdc42 homologue protein
MQTLKCVVVGDGAVGKTCLLISYTTNQFPADYVPTVFDNYAVTVMIGDEPYTLGLFDTAG
QEDYDRLRPLSYPSTDVFLVCFSVISPPSFENVKEKWFPEVHHHCPGVPCLVVGTQIDLR
DDKVIIEKLQRQRLRPITSEQGSRLARELKAVKYVECSALTQRGLKNVFDEAIVAALEPP
VIKKSKKCAIL
Opisthokonta: large supergroup of eukaryotes including metazoans and fungi. In addition, the Opisthokonta also includes some flagellate (choanoflagellates), amoeboid (e.g. Nuclearia) and sporozoan (e.g. Ichthyosporea, Microsporidia) protists.
(From http://www.shigen.nig.ac.jp/algae_tree/OpisthokontaE.html)
Euarchontoglires: taxonomic supergroup of placental mammals that includes primates (apes, monkeys and allies), rodents (mouse, rat and guinea pig), lagomorphs, (rabbit and hares), dermopterans (flying lemurs) and scandentians (tree shrew), and has recently been established exclusively through molecular analyses
(From http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0060019)
Catarrhini: suborder (or infra-order) of primates that includes Old World monkeys, apes, and humans
(From http://www.oxfordreference.com/view/10.1093/acref/9780199233410.001.0001/acref-9780199233410-e-1484)